Multistate models and survival synthesis



Niels Keiding
Department of Biostatistics
University of Copenhagen


Abstract

An important issue in recent biostatistical methodology is to assess, from observational data, the causal effects of a time-dependent treatment or exposure in the presence of time-dependent covariates that may be simultaneously confounders and intermediate variables.

The talk will describe the contributions to this class of problems from event history generalizations of survival analysis and its important complement: survival synthesis, where the many individual transition intensities are synthesized to transition probabilities. It is important to take advantage of the parallel development in biostatistics and sociometrics.

Several approaches have been proposed to handle this issue, among them the dynamic probabilistic causality framework of Arjas and Eerola, and several by James M. Robins (G-computation (being very similar to surival synthesis and the A-E approach), and structural nested failure time models).

The theory will be illustrated with analyses of Bone Marrow Transplant data.