Textbook
by D.L.Hartl and A.G.Clark, 1997 (3rd edition)
The contents of the course
Genetic variation
DNA and protein polymorphisms
random mating and the Hardy-Weinberg principle
multiple loci: linkage disequilibrium
inbreeding coefficient and identity by descent (IBD)
fixation index and Wahlund's principle for metapopulations
Mutation, selection, and migration
irreversible and reversible mutations
selection effects under random mating
overdominance
mutation-selection balance, mutation load
one-way migration and island model of migration
Random genetic drift (RGD)
Wright-Fisher population model
effective population size
diffusion approximations
allele fixation under RGD
the coalescent
infinite alleles model and infinite sites model
RGD-mutation and migration equilibrium
Molecular population genetics
neutral theory of molecular evolution
McDonald-Kreitman test of neutrality
nucleotide polymorphism and diversity
neutral mutation rate estimation
Tajima's test of neutrality
sequence divergence rates
patterns of substitution and replacement, molecular clocks
recombination and polymorphism
gene genalogies
Quantitative genetics
components of the phenotypic variance
breeding value
artificial selection, breeder's equation
resemblance between relatives
heritability of liability to human disease
Wright-Castle index of the QTL number