Cell Intermitotic Time Correlations, Genetic Inheritance and
Leakage Between Cells and Cell Cycle Modelling
Roland Sennerstam
Dept of Pathology, Karolinska Hospital and Institute, Stockholm, Sweden
Abstract
How intermitotic times (IDT) of growing cells are related to each other can be traced by TV-video time-lapse filming experiments. Several reports over the last decades have shown that sister cells have a high correlation of IDT, while mother-daughter cells have either positive, negative or mostley zero coefficients of correlations. This has been discussed without reaching any concensus in how to intepret the data obtained. Experimental errors in registering IDTs is one of several explanations. We present a cell cycle model in a simulation program, where growing cells show high coefficient of correlation between sister cells. At the same time a near zero mother-daughter correlation appeared but a strong cousin-cousin cell IDT correlation was found thereafter. To do this a gowth rate influence was suggested from mother to daughter cells but exerted first in the cousin generation. The possible effect of leakage of substances between cells contributing to growth rate will also be discussed.
